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Dr Mainie provides a tertiary referral service for upper GI patients including complex reflux patients, early oesophageal and stomach cancers, oesophageal motility disorders, endoscopic Ultrasound for cancer staging and therapeutic interventional endoscopy.

He provides a regional service for endotherapy (including endomucosal resection and radiofrequency ablation) for Barrett's oesophagus. Dr Mainie recently represented N Ireland as a regional expert as part of an international group for quality endotherapy for Barrett's oesophagus. He also does General Gastroenterology including the treatment of inflammatory bowel disease and irritable bowel syndrome. Dr Mainie does over 1400 upper and lower endoscopies a year.

He is very active in both national and international research and regularly reviews for international journals. He is the principal Investigator on the SPIT study, BOSS study, HALO registry and also the Hemopspray registry. Recently completed research in the International HALT study for upper GI bleeding. Currently applying for research approval for a Eosinophilic Oesophagitis research trial into biologics. Starting the Cytopsonge study soon.

He has over 55 publications and over 110 abstracts to date. He attends European Gastroenterology meetings regularly as well as the British Society of Gastroenterology meeting.

He is a core member of the Oesophageal Stomach Cancer -NI. Dr Mainie is also the Co Chair for Regional upper GI cancer MDM.

He is a core member on the oesophageal section committee of the British Society of Gastroenterology.

He is actively involved in teaching both local, national and international.

Dr Mainie is an Honorary Lecturer for Queens University Belfast.