Dr Kai-Keen Shiu

I am a Medical Oncology Consultant for the Gastrointestinal Oncology Service at University College London Hospitals NHS Foundation Trust and Honorary Associate Professor at the UCL Cancer Insitute. I treat oesophageal, stomach, small bowel, colorectal and hepatobiliary cancers, as well as cancers of unknown primary. I am the UCLH Clinical Lead for the Cancer of Unknown Primary (CUP) Service and the Acute Oncology Service.

My research interests include immunotherapy for GI malignancies and Cancer of Unknown Primary, with focus on clinical trials and translational research of these cancers. I am Chief Investigator or Principal Investigator for a number of GI or CUP immuno-oncology Phase 2 and 3 trials, including KEYNOTE 177, KEYNOTE 859, KEYNOTE 811, KEYNOTE 975, VESTIGE, POLEM and CUPISCO.

I am Chair of the NCRI MUO-CUP Workstream as part of the Living With and Beyond Cancer CSG, and a member of the NCRI Colorectal Advanced and Adjuvant Disease Subgroup. I am the Principal Investigator of the UCL-UCLH GI + CUP Cancer Translational Research Biobank and a collaborator with the GI Oncology and CUP subgroups at the UCL Cancer Institute and Francis Crick Institute. I am a member of ASCO, ESMO and the Association of Cancer Physicans (UK).

I strongly believe in clinicians being educators and enjoy teaching oncology to UCL medical students, oncology and non-oncology junior trainees. I also give talks nationally and abroad at conferences and other hospitals to share best practice and future perspectives in the fields of GI oncology research, CUP, immunotherapy and novel trial designs.

Diseases, Medical Tests and Treatments

• Gastrointestinal Oncology - oesophageal, stomach, hepatobiliary and bowel cancers
• Cancer of Unknown Primary
• Acute Oncology
• Chemotherapy
• Targeted therapy
• Immunotherapy
• Clinical Trials
• Immunotherapy
• Gastrointestinal Oncology Research
• Cancer of Unknown Primary Research
• Molecular Profiling with solid and liquid biopsies
• Biomarker Driven Clinical Trial Design and Implementation