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Matthew Wilson studied medicine at St Bartholomew's Hospital Medical College in London, qualifying in 1997. He completed his orthopaedic training in Reading, Oxford, Derby, Nottingham and spent time with the Trauma Unit at Massachusetts General Hospital in Boston. He is fellowship trained in Hip Reconstruction by the Exeter Hip Unit and in Hip Preservation Surgery by Mr Richard Villar in Cambridge.

Matthew was appointed as a Consultant, specialising in Hip Reconstructive Surgery, to the Exeter Hip Unit in 2010. He has been a Regional Clinical Coordinator of the National Joint Registry. He is on the Editorial board of the Annals of the Royal College of Surgeons of England and was selected by the American Hip Society as the 2016 Rothman-Ranawat travelling fellow. He has been the Secretary to the Non-Arthroplasty Hip Registry since 2013 and, in 2019, was appointed as Honorary Secretary to the British Hip Society.

Matthew specialises in the diagnosis and management of disorders of the young adult hip, complex primary and revision hip surgery as well as training hip fellows in Exeter and maintaining an interest in research and the long-term outcomes of hip surgery.