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The Alfred is a major tertiary referral teaching hospital located in Melbourne. Founded in 1871, it is the city's oldest hospital still operating on its original site. The hospital was established in honour of Prince Alfred, Duke of Edinburgh, following his survival of an assassination attempt during a visit to Australia. It serves as a cornerstone of Victoria's healthcare system, providing a comprehensive range of specialist medical and surgical services to patients from across the state and country.

The Alfred is recognised for its significant role in providing state-wide and national specialist services. It is one of two major adult trauma centres in Victoria and is home to one of Australia's busiest emergency centres. The hospital contains the largest intensive care unit in the country and provides Victoria's only services for adult heart and lung transplantation. Further specialisations include the Victorian Adults Burn Service and the Victorian Melanoma Service.

As a major teaching hospital, The Alfred is affiliated with Monash University and is a hub for medical research and education. It is part of the Alfred Research Alliance, a consortium of medical research institutions located on-site. The hospital is committed to high-quality patient care that is founded on excellent practice, teaching, and research, ensuring its position at the forefront of medical innovation and treatment.