Dr. Arun Sharma

#multiplesclerosis #treatment #hematopoieticstemcelltransplantation #stemcell #ahsct #neuroscience | Dr Arun Sharma | 10 comments

Multiple sclerosis (MS) is a chronic, inflammatory, and immune-mediated disease of the central nervous system (CNS), primarily affecting young adults and often leading to life-long disability. Currently, about 28 disease-modifying treatments (DMTs) are approved for MS. Despite the availability of these highly effective therapies, some patients continue to experience highly active disease with an aggressive onset and a greater risk of long-term disability. Recent years have seen numerous retrospective studies, clinical trials, meta-analyses, and systematic reviews exploring autologous hematopoietic stem cell transplantation (AHSCT) as a potential treatment option to meet this clinical need. The findings indicate that AHSCT is a highly effective and relatively safe therapeutic approach for treating highly active MS. The body of evidence supporting AHSCT has expanded significantly, particularly in refining patient selection criteria, optimizing transplant techniques, and enhancing clinical experience. AHSCT represents the newest and most effective addition to the therapeutic options available for MS. There is a pressing need to raise global awareness about the applications of stem cell therapies. Thank you for reading and being humans in the middle of the machinist AI maelstrom. #Multiplesclerosis #Treatment #hematopoieticstemcelltransplantation #StemCell #AHSCT #Neuroscience Dr Arun Sharma https://lnkd.in/di2RpGM3 | 10 comments on LinkedIn

ALS: Genetics, Symptoms, and Advances in Treatment | Dr Arun Sharma posted on the topic | LinkedIn

ALS, or amyotrophic lateral sclerosis, is a progressive neurodegenerative disease that impacts both upper and lower motor neurons responsible for movement, speech, swallowing, and breathing. ALS often starts with painless focal weakness, such as foot drop, hand weakness, or difficulties with speech and swallowing, and progressively spreads throughout the body. Over 60 genes have been linked to ALS, making genetic counseling and testing increasingly vital, especially as some therapies target specific mutations like SOD1. While a cure remains elusive, advancements in precision medicine, earlier diagnosis, and personalized care are on the horizon. Gene-targeted therapies, biomarkers, and coordinated care approaches are transforming our understanding of this disease. Six salient advances in understanding this devastating disease include: 1. ALS is not a single disease; genetics reveal multiple biological pathways involved. 2. Early symptoms can be subtle, often resembling orthopedic, spine, or speech-related issues. 3. Multidisciplinary care is crucial and can significantly improve survival and daily functioning. 4. Biomarkers like neurofilament light protein and TDP43 may help identify the disease earlier and track its progression more accurately. 5. The development of therapies such as tofersen demonstrates that targeting the underlying biology of ALS is feasible and may pave the way for future precision treatments. 6. In addition to the purely motor fibers ,other neural networks governing appetite, reward ,and cognition are also involved. 3D- Connectotome / Tractography of a typical ALS patient: video credit to Stanford University #AmyotrophicLateralSclerosis #ALS #MotorNeuronDisease #Neurodegeneration #Neuroscience #DiffusionTensorImaging #Tractography #WhiteMatterPathways #RewardCircuit #Connectotome #LouGherigDisease #GeneTherapy Dr Arun Sharma https://lnkd.in/di2RpGM3 | 10 comments on LinkedIn

Neuroplasticity in Action: Neurons Form Synapses | Dr Arun Sharma posted on the topic | LinkedIn

Watch Neuroplasticity in Action Watching the brain rebuild itself is a fascinating process. In cell culture, neurons extend branching projections known as axons and dendrites as they search for nearby partners. When contact is made, synapses form the communication points that allow neural circuits to emerge. - Neurons explore their environment - Connections form - Networks emerge From these tiny cellular interactions, the complexity of the human brain ultimately arises. This is the essence of neuroplasticity. #Neurons #Neuroscience #Synapses #Neuroplasticity #Axons #Dendrites | 30 comments on LinkedIn