She qualified in 2001 from the University of Padua, Italy, a leading university and one of the oldest in Europe. Dr De Mozzi completed her postgraduate medical training in the UK and obtained Membership of the Royal College of Physicians in 2008. She completed her specialist dermatology training at University Hospitals of Leicester and has been on the Specialist Register since 2014.

Dr De Mozzi worked as a consultant dermatologist, initially at Royal United Hospitals Bath NHS Foundation Trust, where she developed the department's first biologic service for patients with severe psoriasis, as the Biologic Lead for four years. She also undertook the role of Specialty Tutor and led in delivering high-quality dermatology training to junior doctors. Since January 2019 she has been a substantive consultant dermatologist at Royal Free London NHS Foundation Trust.

Dr De Mozzi diagnoses and treats eczema, psoriasis, acne and rosacea, melasma and also covers all areas of general dermatology. She has expertise and a specialist interest in skin cancer diagnosis, treatment and prevention and is qualified to perform dermatological surgery, such as on standard moles, melanomas and other skin cancers.

Another area of specialism of Dr De Mozzi is the impact of the natural ageing and photoageing (caused by sun exposure) process, a major concern in relation to an increasingly ageing population and skin cancer. To broaden her knowledge in this field, she achieved a Skin Ageing and Aesthetic Medicine MSc with Distinction from the University of Manchester in 2017.

Dr De Mozzi has published several dermatology articles in peer-reviewed journals.

She is a member of the British Association of Dermatologists (BAD); British Society for Dermatological Surgery (BSDS); British Medical Laser Association (BMLA); British Cosmetic Dermatology Group (BCDG); and Royal Society of Medicine (RSM).