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Charles Knowles is the Lead for Colorectal Surgery at Cleveland Clinic London and Professor of Surgery at Queen Mary University of London. He has been a Consultant Colorectal surgeon at Barts Health NHS Trust since 2006, after completing his studies at Cambridge University in 1992. He is highly regarded as an international opinion leader on pelvic floor disorders and GI neuromuscular diseases, including common functional colorectal conditions such as chronic constipation and faecal incontinence. His impressive record of delivering quality research and shaping clinical practice is evidenced by his multiple national and international leadership roles, including becoming the inaugural Clinical Director of Research for CCL. He has published extensively in scientific journals (> 270 peer-reviewed papers) and major textbooks.